To integrate an e-signature solution with Salesforce, begin by selecting a compatible provider that supports Salesforce APIs, such as the Salesforce AppExchange. Install the integration app from the AppExchange, configure authentication using OAuth or connected apps, and map Salesforce objects like Opportunities or Contracts to e-signature workflows. Test the integration in a sandbox environment to ensure documents route correctly for signing. For Australian teams, verify the provider's compliance with the Electronic Transactions Act 1999 (Cth) during setup.